Daptomycin dosing in children and adolescents

Indication	Age	Dose^*	Infusion duration
Complicated skin and soft tissue infection	12 to 17 years	5 mg/kg IV once daily	30 minutes
	7 to 11 years	7 mg/kg IV once daily	30 minutes
	2 to 6 years	9 mg/kg IV once daily	60 minutes
	1 to <2 years	10 mg/kg IV once daily	60 minutes
Staphylococcus aureus bacteremia^[1]	12 to 17 years	7 mg/kg IV once daily	30 minutes
	7 to 11 years	9 mg/kg IV once daily	30 minutes
	1 to 6 years	12 mg/kg IV once daily	60 minutes

Dosing shown for moderate to severe infection due to susceptible gram-positive organisms in children and adolescents with normal kidney function. For guidance on antimicrobial choice, refer to UpToDate topic on treatment of invasive Staphylococcus aureus in children or other related infections. Dose adjustment recommendations for children with impaired kidney function are provided in daptomycin drug information included within UpToDate. Experience with daptomycin in children is limited; consultation with an infectious diseases expert may be appropriate.

IV: intravenously.

* Doses based on actual (total) body weight may be rounded to nearest 10 mg depending on local practice and administered once every 24 hours. Further studies are needed to evaluate the appropriateness of daptomycin dosing by total body weight in children and adolescents who are obese (ie, body mass index >30 mg/m²); closer monitoring for toxicity may be warranted in such cases.

Data from:

Arrieta AC, Bradley JS, Popejoy MW, et al. Randomized Multicenter Study Comparing Safety and Efficacy of Daptomycin Versus Standard-of-care in Pediatric Patients With Staphylococcal Bacteremia. Pediatr Infect Dis J 2018; 37:893.
US Food and Drug Administration. Pediatric Postmarketing Pharmacovigilance Review. https://www.fda.gov/media/123630/download.

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Daptomycin dosing in children and adolescents