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Biotin (vitamin H): Pediatric drug information

Biotin (vitamin H): Pediatric drug information
(For additional information see "Biotin (vitamin H): Drug information" and see "Biotin (vitamin H): Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Biotin Extra Strength [OTC] [DSC];
  • Meribin [OTC]
Therapeutic Category
  • Biotinidase Deficiency, Treatment Agent;
  • Nutritional Supplement;
  • Vitamin, Water Soluble
Dosing: Neonatal

Adequate intake (AI): 5 mcg/day (~0.7 mcg/kg/day) (Ref)

Biotinidase deficiency

Biotinidase deficiency: Limited data available: Oral: 5 to 20 mg once daily (Ref)

Dosing: Pediatric
Biotinidase deficiency, symptomatic

Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents: Oral: 5 to 20 mg once daily (Ref)

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Adult

(For additional information see "Biotin (vitamin H): Drug information")

Dietary supplementation

Dietary supplementation (OTC labeling): Oral: Usual dosage: One tablet or capsule daily; also see specific product labeling

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Adverse Reactions

There are no adverse reactions listed in the manufacturer's labeling.

Warnings/Precautions

Other warnings/precautions:

• RDA values: Are not requirements, but are recommended daily intakes of certain essential nutrients.

• Laboratory test interaction: Biotin in blood or other samples taken from patients who are ingesting high levels of biotin from dietary supplements (including multivitamins, prenatal multivitamins, biotin supplements, and dietary supplements for hair, skin, and nail growth) can cause clinically significant incorrect lab test results. Some testing methods use biotin technology (eg, troponin, thyroid function tests, other hormone tests), which use biotin to bind to specific proteins that are measured to detect health conditions. An increase in the number of reported adverse events, including one death, related to biotin interference with lab tests has been reported. If a lab test result does not correspond with a patient's clinical symptoms, biotin interference should be considered as a possible source of error (Bowen 2019; FDA Safety Communication 2019).

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

Meribin: 5 mg

Capsule, Oral [preservative free]:

Biotin Extra Strength: 10 mg [DSC] [gluten free; contains soybean lecithin, soybean oil]

Generic: 5000 mcg

Tablet, Oral:

Generic: 1000 mcg, 5 mg, 10 mg

Tablet, Oral [preservative free]:

Generic: 1000 mcg

Generic Equivalent Available: US

Yes

Pricing: US

Capsules (Meribin Oral)

5 mg (per each): $0.28

Tablets (Biotin Oral)

5 mg (per each): $0.12

1000 mcg (per each): $0.06

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Pediatric

Oral: May be administered without regard to meals; may be preferable to take with meals

Administration: Adult

Oral: May be administered without regard to meals; may be preferable to take with meals

Use

Dietary supplement of biotin (Dietary supplement, consult product specific labeling for manufacturer recommended ages); has also been used to treat biotinidase deficiency

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Dietary Considerations

Adequate intake (IOM 1998):

0 to 6 months: 5 mcg daily (~0.7 mcg/kg)

7 to 12 months: 6 mcg daily (~0.7 mcg/kg)

1 to 3 years: 8 mcg daily

4 to 8 years: 12 mcg daily

9 to 13 years: 20 mcg daily

14 to 18 years: 25 mcg daily

≥19 years: 30 mcg daily

Pregnancy: 30 mcg daily

Lactation: 35 mcg daily

Pregnancy Considerations

Water soluble vitamins cross the placenta (IOM 1998).

Reference Range

Serum biotinidase activity

Mechanism of Action

Functions as a coenzyme; involved in carboxylation, transcarboxylation, and decarboxylation reactions of gluconeogenesis, lipogenesis, fatty acid synthesis, propionate metabolism, and the catabolism of leucine

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AR) Argentina: Biotin a | Panabiotin;
  • (AT) Austria: Bio-h-tin | Curatin | Medobiotin | Merzbiotin;
  • (AU) Australia: Thompson's Biotin;
  • (BR) Brazil: Biotina | Biotina b7 | Biotina supreme | Untral | Vitamina b7;
  • (CH) Switzerland: Biotin merz | Biotin-mepha | Vita Biotin;
  • (CI) Côte d'Ivoire: Biotine Bayer;
  • (CL) Chile: Biotina | Hvit;
  • (CO) Colombia: Biotina;
  • (DE) Germany: Abtei biotin | Apo med biotin | Bio-h-tin | Biodermatin | Biokur | Bioro | Biotin asmedic | Biotin beta | Biotin carin | Biotin h | Biotin Hexal | Biotin impuls | Biotin n | Biotin Ratiopharm | Biotin stada | Biotisan | Biovital biotin | Deacura | DocMorris Biotin | Drofa Vital Biotin N | Gabunat | Haarna mono-biotin | Hana Mono Biotin | Hm Biotin | Kur biotin | Medobiotin | Medobiotin biotin s | Natubiotin | Natuderm | Nobilin Biotin | Priorin biotin | Pure encapsulations biotin | Rombellin | Solaguttae biotin-dragee | Sovita Biotin n | Sunlife biotin | Taxofit biotin | Vitamin B7 | Vitamin h;
  • (EC) Ecuador: Bio T | Nature's bounty biotin;
  • (EE) Estonia: Lamberts biotin | Source naturals biotin;
  • (EG) Egypt: Azgobion | Probiontal;
  • (ES) Spain: Medebiotin;
  • (FI) Finland: Biotisan;
  • (FR) France: Biotine | Qizenday;
  • (GR) Greece: Biotin impuls | Biotin Ratiopharm | Biotine | Medebiotin;
  • (IN) India: Biokare | Biosort | Biotee | Btn | Cosmetin | Cutivit | Essvit | H Vit | Vb7 | Zubitin;
  • (IT) Italy: Biodermatin | Diathynil | Nebiotin;
  • (KE) Kenya: Essvit;
  • (KR) Korea, Republic of: Biotin gold | Dongsung biotin | Nayetin;
  • (LB) Lebanon: Biotine;
  • (LT) Lithuania: Biotin h | Gabunat;
  • (LU) Luxembourg: Biotine;
  • (MA) Morocco: Biotine;
  • (MX) Mexico: Btn;
  • (NO) Norway: Biotin Hexal | Biotin solgar | Cerenday | Gabunat forte | Qizenday;
  • (NZ) New Zealand: Natures own biotin;
  • (PE) Peru: Natures bounty biotin;
  • (PH) Philippines: Wolvit;
  • (PL) Poland: Biotebal | Biotin Ratiopharm | Biotine | Biotynox;
  • (PT) Portugal: Biotina Bayer;
  • (SI) Slovenia: Biotine;
  • (TH) Thailand: Gnc biotin;
  • (TN) Tunisia: Biotine;
  • (TR) Turkey: Avicenna biotin | Bigjoy biotin | Bioak | Day2day biotin | Dynavit biotin | Haver biotin | Hp biotin | Lifextra biotin | Medobiotin | Mrb biotin | Msl biotin | Newita biotin | Newvital biotine | Nutraxin biotin | Orzax ocean biotin | Panplus biotin | Phytodef biotin | Venatura biotin | Vitagil gold biotin | Vitamir biotin | Voonka biotin | Zade vital biotin;
  • (UA) Ukraine: Natubiotin | Volvit;
  • (VE) Venezuela, Bolivarian Republic of: Biotina;
  • (ZA) South Africa: Biotin -vf | Hair, skin & nails
  1. Biotin 5 mcg [prescribing information]. Woodruff, WI: Hillestad Pharmaceuticals Inc.
  2. Biotin 300 mcg [prescribing information]. Livonia, MI: Major Pharmaceuticals; January 2014.
  3. Biotin 1,000 mcg [prescribing information]. Arlington Hts, IL: J.R. Carlson Laboratories, Inc.
  4. Biotin 2,500 mcg [prescribing information]. Fairfield, NJ: Medimetriks Pharmaceuticals, Inc.
  5. Biotin 5,000 mcg [prescribing information]. Bohemia , NY: Nature's Bounty, Inc; 2013.
  6. Biotin 10,000 mcg [prescribing information]. Bohemia , NY: Nature's Bounty, Inc; 2012.
  7. Bowen R, Benavides R, Colón-Franco JM, et al. Best practices in mitigating the risk of biotin interference with laboratory testing. Clin Biochem. 2019;74:1-11. doi:10.1016/j.clinbiochem.2019.08.012 [PubMed 31473202]
  8. Food & Drug Administration (FDA). Update: The FDA warns that biotin may interfere with lab tests: FDA Safety Communication. 2019. https://www.fda.gov/medical-devices/safety-communications/update-fda-warns-biotin-may-interfere-lab-tests-fda-safety-communication. Updated November 5, 2019. Accessed November 6, 2019.
  9. IOM (Institute of Medicine), Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B 6 , Folate, Vitamin B 12 , Pantothenic Acid, Biotin and Choline, Washington, DC: National Academy Press, 1998.
  10. Kummer S, Hermsen D, Distelmaier F. Biotin treatment mimicking Graves' disease. N Engl J Med. 2016;375(7):704-706. doi:10.1056/NEJMc1602096 [PubMed 27532849]
  11. Maximum Strength Biotin 5,000 mcg [prescribing information]. Tempe, AZ: 21st Century HealthCare, Inc.
  12. Maximum Strength Biotin 800 mcg [prescribing information]. Tempe, AZ: 21st Century HealthCare, Inc.
  13. McVoy JR, Levy HL, Lawler M, et al. Partial biotinidase deficiency: clinical and biochemical features. J Pediatr. 1990;116(1):78-83. [PubMed 2295967]
  14. Micó SI, Jiménez RD, Salcedo EM, Martínez HA, Mira AP, Fernández CC. Epilepsy in biotinidase deficiency after biotin treatment. JIMD Rep. 2012;4:75-78. [PubMed 23430899]
  15. Salbert BA, Pellock JM, and Wolf B. Characterization of seizures associated with biotinidase deficiency. Neurology. 1993;43(7):1351-1355. [PubMed 8327137]
  16. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy of Sciences, Washington, DC: National Academy Press. 1998. Available at http://www.nap.edu
  17. Wastell HJ, Bartlett K, Dale G, et al, “Biotinidase Deficiency: A Survey of 10 Cases,” Arch Dis Child, 1988, 63(10):1244-9. [PubMed 3196050]
  18. Wolf B. Biotinidase deficiency: new directions and practical concerns. Curr Treat Options Neurol. 2003;5(4):321-328. [PubMed 12791199]
  19. Wolf B. Clinical issues and frequent questions about biotinidase deficiency. Mol Genet Metab. 2010;100(1):6-13. [PubMed 20129807]
  20. Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008 Nov;3(6):715-724. [PubMed 19727438]
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