Adequate intake (AI): 5 mcg/day (~0.7 mcg/kg/day) (Ref)
Biotinidase deficiency: Limited data available: Oral: 5 to 20 mg once daily (Ref)
Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents: Oral: 5 to 20 mg once daily (Ref)
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
(For additional information see "Biotin (vitamin H): Drug information")
Dietary supplementation (OTC labeling): Oral: Usual dosage: One tablet or capsule daily; also see specific product labeling
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no adverse reactions listed in the manufacturer's labeling.
Other warnings/precautions:
• RDA values: Are not requirements, but are recommended daily intakes of certain essential nutrients.
• Laboratory test interaction: Biotin in blood or other samples taken from patients who are ingesting high levels of biotin from dietary supplements (including multivitamins, prenatal multivitamins, biotin supplements, and dietary supplements for hair, skin, and nail growth) can cause clinically significant incorrect lab test results. Some testing methods use biotin technology (eg, troponin, thyroid function tests, other hormone tests), which use biotin to bind to specific proteins that are measured to detect health conditions. An increase in the number of reported adverse events, including one death, related to biotin interference with lab tests has been reported. If a lab test result does not correspond with a patient's clinical symptoms, biotin interference should be considered as a possible source of error (Bowen 2019; FDA Safety Communication 2019).
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule, Oral:
Meribin: 5 mg
Capsule, Oral [preservative free]:
Biotin Extra Strength: 10 mg [DSC] [gluten free; contains soybean lecithin, soybean oil]
Generic: 5000 mcg
Tablet, Oral:
Generic: 1000 mcg, 5 mg, 10 mg
Tablet, Oral [preservative free]:
Generic: 1000 mcg
Yes
Capsules (Meribin Oral)
5 mg (per each): $0.28
Tablets (Biotin Oral)
5 mg (per each): $0.12
1000 mcg (per each): $0.06
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Oral: May be administered without regard to meals; may be preferable to take with meals
Oral: May be administered without regard to meals; may be preferable to take with meals
Dietary supplement of biotin (Dietary supplement, consult product specific labeling for manufacturer recommended ages); has also been used to treat biotinidase deficiency
None known.
There are no known significant interactions.
Adequate intake (IOM 1998):
0 to 6 months: 5 mcg daily (~0.7 mcg/kg)
7 to 12 months: 6 mcg daily (~0.7 mcg/kg)
1 to 3 years: 8 mcg daily
4 to 8 years: 12 mcg daily
9 to 13 years: 20 mcg daily
14 to 18 years: 25 mcg daily
≥19 years: 30 mcg daily
Pregnancy: 30 mcg daily
Lactation: 35 mcg daily
Water soluble vitamins cross the placenta (IOM 1998).
Serum biotinidase activity
Functions as a coenzyme; involved in carboxylation, transcarboxylation, and decarboxylation reactions of gluconeogenesis, lipogenesis, fatty acid synthesis, propionate metabolism, and the catabolism of leucine
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