Comparison of device-assisted and lesioning procedures for Parkinson disease

	VIM DBS	STN or GPi DBS	LCIG	CSAI	Conventional pallidotomy	FUS thalamotomy	FUS pallidotomy
Indications	Refractory PD tremor	Motor fluctuations or refractory PD tremor	Motor fluctuations	Motor fluctuations	Motor fluctuations	Refractory PD tremor	Motor fluctuations
Can be performed bilaterally?	No	Yes	N/A	N/A	No	No	No
Surgery required?	Yes, scalp incision/burr hole	Yes, scalp incision/burr hole	Yes, PEG-J placement	No	Yes	No	No
Intentional brain lesion?	No	No	No	No	Yes	Yes	Yes
Reversible?	Yes	Yes	Yes	Yes	No	No	No
Randomized, placebo, or sham-controlled trial data available?	No	Yes	Yes	Yes	Randomized trial with blinded evaluators	Yes	Yes
Long-term data (>2 years) available?	Yes	Yes	Yes	Yes	Yes	No	No
Clinical availability	Full	Full	Full	Not approved for use in United States	Full	Limited number of centers	Limited number of centers

VIM: ventral intermediate nucleus; DBS: deep brain stimulation; STN: subthalamic nucleus; GPi: internal globus pallidus; LCIG: levodopa-carbidopa intestinal gel; CSAI: continuous subcutaneous apomorphine infusion; FUS: focused ultrasound (magnetic resonance-guided); PD: Parkinson disease; PEG-J: percutaneous endoscopic gastrostomy jejunostomy.

Graphic 130126 Version 2.0

خرید پکیج

Comparison of device-assisted and lesioning procedures for Parkinson disease