Version June 2024
| Gene | Characteristic association |
| CDKN2A | Familial melanoma |
| BRAF | Most common mutations in sporadic melanoma |
| PTEN | Common |
| NRAS | Enriched in nodular melanoma |
| HRAS | Present in some Spitz nevi, distinguishing them from spitzoid melanoma |
| ALK | ALK fusions in subset of Spitz neoplasms |
| KIT | Predilection for lentigo maligna melanoma, acral lentiginous melanoma, mucosal melanomas |
| GNAQ, GNA11 | Uveal melanoma, blue nevi |
| BAP1 | Associated with epithelioid Spitz tumors, uveal melanoma, mesothelioma, renal cell carcinoma |
| TERT | Encodes for telomerase; can be associated with high-risk spitzoid melanoma |
| NTRK | Gene fusions frequently associated with infantile fibrosarcoma and secretory type of breast cancer; TRK inhibitors available |
| NF1 | Occurs with mutations in the RASopathy genes |
| IDH1 | 3 to 5% of melanomas |
| RAC1 | Common |
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