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Our suggested approach to the evaluation of patients with suspected COVID-19-associated multisystem inflammatory syndrome in children (MIS-C)

Our suggested approach to the evaluation of patients with suspected COVID-19-associated multisystem inflammatory syndrome in children (MIS-C)

COVID-19: coronavirus disease 2019; KD: Kawasaki disease; TSS: toxic shock syndrome; MIS-C: multisystem inflammatory syndrome in children; CBC: complete blood count; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; BUN: blood urea nitrogen; LFT: liver function test; LDH: lactate dehydrogenase; PT: prothrombin time; INR: international normalized ratio; aPTT: activated partial thromboplastin time; BNP: brain natriuretic peptide; NT-pro-BNP: N-terminal pro-BNP; ECG: electrocardiogram; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; PCR: polymerase chain reaction; CDC: Centers for Disease Control and Prevention; LVEF: left ventricular ejection fraction; CA: coronary artery; GI: gastrointestinal; RNA: ribonucleic acid; RT-PCR: reverse transcription polymerase chain reaction; WHO: World Health Organization; EBV: Epstein-Barr virus; CMV: cytomegalovirus.

* In children with moderate or severe manifestations, testing for other pathogens generally includes blood, urine, stool, and throat cultures; respiratory viral panel; and testing for EBV, CMV, enterovirus, and adenovirus. In children presenting with mild symptoms, microbiologic testing should be done as clinically indicated according to the age of the child and their specific symptoms (eg, throat culture if the child has a sore throat, respiratory viral panel if there are respiratory symptoms).
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