Version May 2024
Herpes keratoconjunctivitis, keratitis: Children ≥6 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye every 2 hours while awake, to a maximum of 9 drops/day, until re-epithelialization of corneal ulcer occurs; then use 1 drop every 4 hours for another 7 days (minimum daily dosage of 5 drops is recommended). Do not exceed 21 days of treatment; if improvement has not taken place in 7 to 14 days, consider another form of therapy.
There are no dosage adjustments provided in the manufacturer's labeling, however, dosage adjustment unlikely needed due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling, however, dosage adjustment unlikely needed due to low systemic absorption.
(For additional information see "Trifluridine: Drug information")
Herpes keratoconjunctivitis, keratitis: Ophthalmic: Instill 1 drop into affected eye(s) every 2 hours while awake, to a maximum of 9 drops/day, until re-epithelialization of corneal ulcer occurs; then use 1 drop every 4 hours while awake for another 7 days (minimum daily dosage of 5 drops is recommended). Do not exceed 21 days of treatment; if improvement has not taken place in 7 to 14 days, consider another form of therapy.
Herpes simplex virus infection, mucocutaneous (acyclovir resistant) (alternative agent) (off-label use): Patients with HIV: Topical: Apply 3 times daily for ≥21 to 28 days, based on clinical response (Ref).
Mpox (monkeypox) ocular infection, treatment or prophylaxis (adjunctive agent) (off-label use): Topical: Instill 1 drop into affected eye(s) every 2 hours while awake (maximum: 9 drops/eye per day) for the first 2 weeks, then 4 times daily for an additional 2 weeks (Ref).
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%:
Ophthalmic: Burning sensation of eyes (≤5%), stinging of eyes (≤5%), eyelid edema (3%)
Frequency not defined:
Hypersensitivity: Local ocular hypersensitivity reaction
Ophthalmic: Dry eye syndrome, epithelial keratopathy, eye irritation, hyperemia, increased intraocular pressure, ocular stromal edema, superficial punctate keratitis
Known hypersensitivity to trifluridine or any component of the formulation
Concerns related to adverse effects:
• Irritation: Mild local irritation of conjunctival and cornea may occur when instilled; effects are usually transient.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic:
Generic: 1% (7.5 mL)
Yes
Solution (Trifluridine Ophthalmic)
1% (per mL): $29.73
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic:
Viroptic: 1% (7.5 mL) [contains benzalkonium chloride]
Generic: 1% (7.5 mL)
Ophthalmic: Wash hands before and after instillation. Avoid contact of bottle tip with skin or eye; instill drops onto the cornea of the affected eye(s). Apply gentle pressure to lacrimal sac during and immediately following instillation (1 minute) or instruct patient to gently close eyelid after administration, to decrease systemic absorption of ophthalmic drops (Ref).
For ophthalmic use only; avoid touching tip of applicator to eye or other surfaces. Wash hands before and after instillation.
Store refrigerated at 2°C to 8°C (36°F to 46°F).
Treatment of primary keratoconjunctivitis and recurrent epithelial keratitis caused by herpes simplex virus types I and II (FDA approved in ages ≥6 years and adults)
Viroptic may be confused with Timoptic.
None known.
There are no known significant interactions.
Adverse effects have not been observed during animal reproduction studies of the ophthalmic solution. Systemic absorption following ophthalmic application is limited. If ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctal occlusion to decrease potential exposure to the fetus (Samples 1988).
Ophthalmologic exam (test for corneal staining with fluorescein or rose Bengal)
Interferes with viral replication by inhibiting thymidylate synthetase and incorporating into viral DNA in place of thymidine (Carmine 1982).
Absorption: Ophthalmic: Systemic absorption negligible, corneal penetration adequate
Half-life elimination: ~12 minutes
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