Regimen | Drug | Dose, route | Schedule (28-day cycle except as otherwise noted) |
Methotrexate, temozolomide, rituximab (MTR)[1] | MTX | 8 g/m2 IV* | Days 1, 15 |
TMZ | 150 mg/m2 per day, PO | Days 7 through 11 | |
RTX | 375 mg/m2 IV | Weekly starting on day 3 of cycle 1, for 6 total doses¶ | |
Methotrexate, procarbazine, vincristine, rituximab (R-MPV)[2] | MTX | 3.5 g/m2 IV*Δ | Days 2, 16 |
PRO | 100 mg/m2 per day, PO | Days 7 through 13 | |
VCR | 1.4 mg/m2 (max 2.8 mg) IV | Days 2, 16 | |
RTX | 500 mg/m2 IV | Days 1, 15 | |
Methotrexate, cytarabine, thiotepa, rituximab (MATRix)[3] | 21-day cycle: | ||
MTX | 3.5 g/m2 IV* |
| |
Cytarabine | 2 g/m2 every 12 hours IV |
| |
Thiotepa | 30 mg/m2 IV |
| |
RTX | 375 mg/m2 IV |
| |
Methotrexate, carmustine, etoposide, prednisone, rituximab (R-MBVP)[4] | MTX | 3 g/m2 IV* | Days 1, 15 |
Carmustine | 100 mg/m2 IV | Day 3 | |
Etoposide | 100 mg/m2 IV | Day 2 | |
Prednisone | 60 mg/kg per day, PO | Days 1 through 5 | |
RTX | 375 mg/m2 IV | Day 1 |
MTX: methotrexate; TMZ: temozolomide; RTX: rituximab; IV: intravenous; PO: by mouth; PRO: procarbazine; VCR: vincristine.
* With leucovorin rescue.
¶ Patients with T cell primary central nervous system lymphoma did not receive RTX.
Δ Intraventricular MTX 12 mg via Ommaya reservoir administered between days 5 and 12, and 19 and 26 of each cycle for patients with positive cerebrospinal fluid (CSF) cytology.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟