Muscle RNAseq data implicates interferon-beta in dermatomyositis

(A) Selective elevation of interferon-beta (IFNB) 1 among other type 1 interferons in dermatomyositis muscle.
(B) Specificity of IFNB1 elevation in dermatomyositis compared with other inflammatory myopathies and healthy muscle.

RNAseq: RNA sequencing; DM: dermatomyositis; FPKM: fragments per kilobase of exon model per million reads mapped; IFNA: interferon-alpha; IFNB: interferon-beta; IFNE: interferon-epsilon; IFNK: interferon-kappa; IFNW: interferon-omega; anti-SS: antisynthetase syndrome; IBM: inclusion body myositis; IMNM: immune-mediated necrotizing myopathy.

Data from: Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies. National Institutes of Health, Muscle Disease Unit, Dataset GSE143323. Available at: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE143323 (Accessed on April 15, 2020).

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خرید پکیج

Muscle RNAseq data implicates interferon-beta in dermatomyositis