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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Laboratory features associated with severe COVID-19[1-6]

Laboratory features associated with severe COVID-19[1-6]
Abnormality Possible threshold
Elevations in:
  • D-dimer
 >1000 ng/mL (normal range: <500 ng/mL)
  • CRP
 ≥75 mg/L (normal range: <8.0 mg/L)
  • LDH
 >245 units/L (normal range: 110 to 210 units/L)
  • Troponin
 >2× the upper limit of normal (normal range for troponin T high sensitivity: females 0 to 9 ng/L; males 0 to 14 ng/L)
  • Ferritin
 >500 mcg/L (normal range: females 10 to 200 mcg/L; males 30 to 300 mcg/L)
Decrease in:
  • Absolute lymphocyte count
 <800/microL (normal range for age ≥21 years: 1000 to 4800/microL)
Although these laboratory features are associated with severe disease in patients with COVID-19, they have not been clearly demonstrated to have prognostic value. We use the thresholds listed above to identify patients who may be at risk for severe disease; they are extrapolated from published cohort data and individualized to the reference values used at our laboratory. However, the specific thresholds are not well established and may not be applicable if laboratories use other reference values.
COVID-19: coronavirus disease 2019; CRP: C-reactive protein; LDH: lactate dehydrogenase; CPK: creatine phosphokinase.
References:
  1. Guan WY, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020.
  2. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395:497.
  3. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395:1054.
  4. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020.
  5. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020.
  6. Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med 2020.
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