Antimicrobial prophylaxis regimens for patients with multiple myeloma*

Antibacterial

Levofloxacin 500 or 750 mg orally once daily

Antiviral

HSV and VZV

Acyclovir

For HSV: 400 or 800 mg orally twice daily

For VZV: 800 mg orally twice daily

Valacyclovir 500 mg orally twice daily

Pneumocystis

Preferred regimen:

Trimethoprim-sulfamethoxazole one single-strength tablet orally once daily or one double-strength tablet orally once daily or three times weekly^¶

Alternative regimens:

Dapsone 100 mg orally once daily or 50 mg orally twice daily

Pentamidine 300 mg by aerosol every four weeks

Atovaquone 1500 mg orally once daily with a high-fat meal

The doses above are intended for patients with normal renal function. The doses of many of the agents listed above must be adjusted in the setting of renal insufficiency. Many of the agents listed above can be given IV if the patient is unable to take oral medications. Refer to the Lexicomp drug specific monograph for renal dose adjustments and IV dosing.

HSV: herpes simplex virus; VZV: varicella-zoster virus; CMV: cytomegalovirus; IV: intravenously.
* Refer to the associated topic review for indications for antimicrobial prophylaxis.
¶ Trimethoprim-sulfamethoxazole is preferred as it is the most effective regimen for Pneumocystis prophylaxis.

Graphic 126356 Version 1.0

خرید پکیج

Antimicrobial prophylaxis regimens for patients with multiple myeloma*