(A) Photomicrograph of melasma. Hematoxylin and eosin stain. Increased epidermal melanin and mild, perivascular, lymphohistiocytic infiltrate (original magnification 340).
(B) Hematoxylin and eosin stain. Normal skin for comparison. Same patient (original magnification 340).
From: Grimes PE, Yamada N, Bhawan J. Light microscopic, immunohistochemical, and ultrastructural alterations in patients with melasma. Am J Dermatopathol 2005; 27:96. DOI:
10.1097/01.dad.0000154419.18653.2e. Copyright © 2005. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.