Congestive hepatic fibrosis staging

(Panel A) Congestive hepatic fibrosis stage (CHFS) 1 consisting of central zone fibrosis. This photomicrograph shows delicate perisinusoidal fibrosis in perivenular areas (zone 3). Masson trichrome stain, original magnification ×40.
(Panel B) CHFS stage 2. In addition to central zone fibrosis, there is portal fibrosis. In this photomicrograph, there is accentuation of the central zone (thick arrow) while the portal area on the left is also expanded (arrows). Masson trichrome stain, original magnification ×10.
(Panel C) CHFS stage 3. Irregular bands of fibrous tissue link portal to central and central to central zones. Dense fibroconnective tissue is shown linking an expanded portal tract to centrilobular zone (thick arrow). Masson trichrome stain, original magnification ×10.
(Panel D) CHFS stage 4. The hepatic architecture is completely altered by nodule formation. Shown in the photomicrograph is an irregular nodule comprised of atrophic hepatocytes that are bordered by irregular bands of fibroconnective tissue. Masson trichrome stain, original magnification ×20.