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Medication selection for RSI in adults by clinical setting

Medication selection for RSI in adults by clinical setting
Clinical scenario Induction agent* Neuromuscular blocking agent* Physiologic optimization
(including pre-induction medications)Δ
Elevated ICP (head injury, stroke) Etomidate 0.3 mg/kg IV or ketamine 1 to 2 mg/kg IV (avoid ketamine if signs of cerebral herniation; ketamine preferred in patients with severe hypotension) Succinylcholine 1.5 mg/kg IV or rocuronium 1.5 mg/kg IV May give fentanyl 3 mcg/kg IV over 30 to 60 seconds, if time permits and patient is not in shock, for conditions exacerbated by rise in ICP (eg, acute brain injury, ischemic stroke, intracranial hemorrhage, meningitis, encephalitis, cerebral edema)
Cardiovascular emergency excluding cardiogenic shock (ACS, aortic dissection) Etomidate Succinylcholine or rocuronium May give fentanyl 3 mcg/kg IV over 30 to 60 seconds, if time permits
Shock Ketamine or etomidate (reduce dose by half for cardiogenic shock; ketamine preferred by some for septic shock) Succinylcholine 2 mg/kg IV or rocuronium Pre-RSI management depends on cause and may include:
  • Hypovolemic shock: Isotonic IVF bolus
  • Hemorrhagic shock: Blood transfusion
  • Septic shock: Isotonic IVF bolus; vasopressor (norepinephrine)
Reactive airway disease
Stable blood pressure Ketamine or propofol 1.5 to 2 mg/kg IV Succinylcholine or rocuronium Pre-RSI management may include NPPV, heliox, high-flow oxygen (in addition to albuterol and other standard medical therapy)
Hypotensive/unstable Ketamine or etomidate Succinylcholine or rocuronium  
Prolonged seizure activity Propofol or etomidate Succinylcholine preferred (rocuronium may be used if EEG monitoring immediately available)  
Geriatric patient Etomidate preferred (reduce dose by half if frail, hypotensive, or significant comorbidity) Succinylcholine or rocuronium Physiologic optimization may include isotonic IVF bolus, blood transfusion, and/or vasopressor (norepinephrine) infusion for hypotensive patients or those at risk of hypotension with RSI
RSI: rapid sequence intubation; ICP: intracranial pressure; IV: intravenous; ACS: acute coronary syndrome; IVF: intravenous fluids; EEG: electroencephalogram; NPPV: noninvasive positive pressure ventilation; ECG: electrocardiogram.

* Standard dose is provided once in the table but is the same for all conditions unless otherwise specified.
¶ Succinylcholine is contraindicated with:
  • Malignant hyperthermia (patient or family history)
  • Neuromuscular disease with denervation
  • Muscular dystrophy
  • Stroke over 72 hours old
  • Rhabdomyolysis
  • Significant burn over 72 hours old
  • Hyperkalemia with ECG changes
Δ For more details about physiologic optimization, please refer to the UpToDate topics on RSI.
Graphic 122488 Version 3.0

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