Histologic and molecular features of appendiceal serrated lesions and polyps

Polyp type	Histologic features			Molecular features
Polyp type	Crypts	Cytological dysplasia	Architecture	KRAS mutation	BRAF mutation
Hyperplastic polyp	Straight crypts with serration limited to luminal aspect of the crypt	Absent	Discrete polyp or circumferential mucosal involvement; villous growth uncommon	Often present	Rarely present
Serrated lesion without dysplasia	Distorted crypts with serration and crypt dilatation extending to crypt bases	Absent	Often with circumferential mucosal involvement; villous growth uncommon	Typically present	Rarely present
Serrated lesion with dysplasia	Distorted crypts with serration and crypt dilatation extending to crypt bases	Present	Often with circumferential mucosal involvement; villous growth variable	Typically present	Rarely present

Reprinted with permission from: WHO Classification of Tumours. Digestive System Tumours, 5th ed, Nagtegaal ID, Klimstra DS, Washington MK, the WHO Classification of Tumours Editorial Board (Ed), Tumours of the appendix, p.142, Copyright © 2019 International Agency for Research on Cancer.

Graphic 122431 Version 1.0

خرید پکیج

Histologic and molecular features of appendiceal serrated lesions and polyps