Tubulointerstitial changes and arteriolar hyalinosis in diabetic kidney disease

Tubulointerstitial changes in diabetic kidney disease.
(A) Normal renal cortex.
(B) Thickened tubular basement membranes and interstitial widening (arrow).
(C) Arteriole with an intimal accumulation of hyaline material with significant luminal compromise (arrowhead).
(D) Renal tubules and interstitium in advancing diabetic kidney disease, with thickening and wrinkled tubular basement membranes (double arrow), atrophic tubules (thick arrow), some containing casts, and interstitial widening with fibrosis and inflammatory cells (dashed arrow). All sections were stained with period acid–Schiff stain. Original magnification, x200.