Frequencies of different types of F8 and F9 DNA variants in hemophilia A and B

The pie charts show the distribution of types of variants in the F8 gene in males with hemophilia A and the F9 gene in males with hemophilia B. The types of variants differ for severe disease (left-hand side) and mild to moderate disease (right-hand side). For both hemophilia A and B, structural and nonsense variants predominate in severe disease, whereas missense variants are most common in mild to moderate disease.
(A) Hemophilia A; F8 variants
(B) Hemophilia B; F9 variants