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Conceptual model of the natural history of diabetic kidney disease

Conceptual model of the natural history of diabetic kidney disease
Duration of diabetes, in years, is presented on the horizontal axis. Timeline is well characterized for type 1 diabetes mellitus; for type 2 diabetes mellitus, timeline may depart from the illustration due to the variable timing of the onset of hyperglycemia.
GFR: glomerular filtration rate; ESKD: end-stage kidney disease.
* Anemia, bone and mineral metabolism, retinopathy, and neuropathy.
Reproduced with permission from: Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: Challenges, progress, and possibilities. Clin J Am Soc Nephrol 2017; 12:2032. Copyright © 2017 American Society of Nephrology. All rights reserved.
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