Clinical staging for medication-related osteonecrosis of the jaw (MRONJ) from the International Task Force on Osteonecrosis of the Jaw

Stage	Clinical description
1	Asymptomatic Exposed bone on mandible or maxilla No evidence of significant adjacent or regional soft tissue inflammation or secondary infection
2	Painful Exposed bone on mandible or maxilla Adjacent or regional soft tissue inflammation or secondary infection
3	Painful Exposed bone on mandible or maxilla Adjacent or regional soft tissue inflammation or secondary infection Extraoral fistula or oral antral fistula or radiographic evidence of osteolysis extending to the inferior border of the mandible or the floor of the maxillary sinus

Reproduced with permission from: Aliya A. Khan. Originally published in: Khan AA, Morrison A, Hanley DA, et al. Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus. J Bone Miner Res 2015; 30:3. Copyright © 2015 Khan AA, Morrison A, Hanley DA, et al.

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Clinical staging for medication-related osteonecrosis of the jaw (MRONJ) from the International Task Force on Osteonecrosis of the Jaw