Allometric dosing of miltefosine for treatment of visceral leishmaniasis in children <12 years

Total daily allometric miltefosine dose (mg) for patient of indicated height (cm)*
Weight (kg)	60	70	80	90	100	110	120	130	140	150	175	200
Males
9	30	40	40	40	40
12	40	40	40	50	50	50
15		40	50	50	60	60	60
20			50	60	60	70	70	70
25				60	70	70	80	80	80
30					80	80	90	90	90	100
35					80	90	90	100	100	100	110
40					80	90	100	100	110	110	120	130
45					90	90	100	110	110	120	130	130
50					90	100	100	110	120	120	130	140
55					90	100	110	120	120	130	140	150
60					90	100	110	120	130	130	150	150^¶
65					100	110	110	120	130	140	150	150^¶
75					100	110	120	130	140	140	150^¶	150^¶
85					100	110	120	130	140	150	150^¶	150^¶
Females
9	30	30	30	30	30
12	30	30	40	40	40	40
15		40	40	40	50	50	50
20			50	50	50	60	60	60
25				60	60	60	70	70	70
30				60	60	70	70	80	80	80
35				60	70	70	80	80	80	90	90
40				70	70	80	80	90	90	90	100	110
45				70	80	80	90	90	100	100	110	110
50				70	80	80	90	100	100	100	110	120
55				70	80	90	90	100	100	110	120	130
60				70	80	90	100	100	110	110	120	130
65				80	80	90	100	110	110	120	130	140
75				80	90	100	100	110	120	120	140	150
85				80	90	100	110	120	120	130	150	150^¶

* The total daily dose was calculated with equation 6 and rounded to the nearest 10 mg (smallest available capsule). To reduce the risk of gastrointestinal side effects upon intake, daily doses are best divided into 3 and given with 8 hour intervals between doses.

¶ A dose of 150 mg is considered to be the maximal tolerable dose that can be administered on a daily basis to a patient.

From: Dorlo TPC, Huitema ADL, Beijnen JH, de Vries PJ. Optimal dosing of miltefosine in children and adults with visceral leishmaniasis. Antimicrobial Agents and Chemotherapy 2012; 56:3864. DOI: 10.1128/AAC.00292-12. Copyright © 2012 American Society for Microbiology. Reproduced with permission from American Society for Microbiology.

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Allometric dosing of miltefosine for treatment of visceral leishmaniasis in children <12 years