Intervention | For use with contraceptive types | Dose | Duration | Notes |
Observation with consistent and correct use of contraceptive | All | N/A | N/A | Incidence of unscheduled bleeding is highest in the first few months of contraceptive use and then decreases |
Ibuprofen | All | 400 mg orally three times a day | 5 to 10 days | Limited data but is low risk, low cost, generally well tolerated, and readily available |
Supplemental estrogen only | Progestin-only contraceptives | Cannot be used by women with contraindications to estrogen therapy* | ||
Conjugated estrogen | 1.25 mg orally daily | 7 days | ||
Estradiol | 2 mg orally daily | 7 days | ||
Combined estrogen-progestin contraceptive (pill, patch, or ring) | Progestin-only contraceptives | For oral pill: 1 tablet daily¶ | 10 to 20 days | Cannot be used by women with contraindications to estrogen therapy* |
Change in dose/formulation of estrogen-progestin contraceptive | Estrogen-progestin contraceptives | Contraceptive vaginal ring Different dose or formulation of pillΔ | As directed for method | Limited supporting data |
Mefenamic acid | Progestin-only contraceptives | 500 mg orally once a day | 5 days | In one trial, treatment with mefenamic acid was not statistically different from placebo by 4 weeks of treatment |
Tranexamic acid | Progestin-only contraceptives | 650 mg orally twice a day | 5 days | One supporting trial used 250 mg 4 times daily, which is not a standardly available dose Risk of thrombosis is unknown |
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