Oral antibiotic regimens with activity against group A Streptococcus

Oral antibiotic regimens with activity against group A Streptococcus

	Adults	Children
Penicillin V	250 to 500 mg 4 times per day	In absence of GAS pneumonia: 25 to 50 mg/kg/day divided in 4 doses [maximum 2 g/day] In presence of GAS pneumonia: 50 to 75 mg/kg/day divided in 4 doses [maximum 2 g/day]
Amoxicillin	875 mg twice daily or 500 mg 3 times per day	40 to 45 mg/kg/day divided in 3 doses [maximum 3 g/day]
Cephalexin*	500 mg 4 times per day	25 to 50 mg/kg/day divided in 3 doses [maximum 3 g/day]
Clindamycin*	300 to 450 mg 3 times per day	30 to 40 mg/kg/day divided in 3 doses [maximum 1800 mg/day]

GAS: Group A Streptococcus.
* Cephalexin and clindamycin are alternative agents for patients with hypersensitivity to penicillin.

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