Version May 2024
| Complication | Types of MPS |
| Respiratory | |
| Central apnea from cord compression | MPS IV A and B; also occurs in other types |
| Airway obstruction | MPS I, II, VI, and VII |
| Sinopulmonary infectious | All MPS types |
| Pulmonary function abnormalities | MPS I, II, IVA, VI, and VII |
| Cardiac | |
| Valvular disease | MPS I, II, and VI; less commonly in MPS III A to D |
| Vascular disease | MPS IH (untreated) |
| Pulmonary hypertension | Secondary usually to severe OSA |
| Skeletal and connective tissue | |
| Dysostosis multiplex | MPS I, II, IV, VI, and VII; less extensive in MPS III |
| Odontoid hypoplasia | MPS IV A and B; severe forms of MPS I and VII |
| Kyphoscoliosis | MPS I, II (less common), IV, VI, and VII |
| Genu valgum | Majority of patients with MPS IV A and B; can occur in other types |
| Short stature | MPS I, II, IVA, VI, and VII |
| Joint stiffness and degenerative disease | Nearly all MPS patients |
| Ligamentous laxity | Most often in MPS IV A and B |
| Hernias | Especially in MPS I, II, VI, and VII |
| Neurologic | |
| Developmental delay and neurologic decline | Severe forms of MPS I, II, III, and VII |
| Abnormal behavior | Severe MPS II and III (less common in severe MPS I) |
| Seizures | MPS II, MPS III; rarely seen in other MPS disorders |
| Sleep disturbance | Common, especially in MPS II and III |
| Hydrocephalus | MPS I, II, VI, and VII |
| Cervical cord compression | MPS I, II (less common), IV, VI, and VII |
| Pachymeningitis cervicalis | MPS I, II, VI, and VII |
| C1-C2 subluxation | Common in MPS IV A and B; also occurs in MPS I, VI, and VII |
| Carpal tunnel syndrome | MPS I, II, VI, and VII |
| Recurrent or chronic diarrhea | MPS II and III |
| Ophthalmologic | |
| Corneal clouding | MPS I, IV, VI, and VII |
| Glaucoma | MPS I, II, and VI |
| Optic neuropathy | MPS I, II, and VI |
| Degeneration of the retina | MPS I, II, III, VI, and VII |
| Otolaryngologic | |
| Hearing loss | All MPS types |
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