High-risk for severe infection or complications (1 or more) |
ANC <500 cells/microL* anticipated to last for >7 days |
Evidence of hepatic insufficiency (aminotransferase levels >5 times normal values) |
Evidence of renal insufficiency (creatinine clearance <30 mL/min) |
Comorbid medical problems including, but not limited to:
|
Acute lymphoblastic leukemia in infant <12 months of age |
Acute myeloid leukemia |
Within 30 days of hematopoietic cell transplant¶ |
Low-risk for severe infection or complications (all) |
ANC <500 cells/microL expected to resolve within 7 days (ie, neutrophil count increasing) |
Stable and adequate hepatic function |
Stable and adequate renal function |
No active comorbidities (as listed above) |
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