Drugs that reduce the effect of dopamine in the brain

Type of drug	Antidopaminergic mechanism	Examples
First-generation antipsychotics	D2R antagonism (high potency)	Droperidol Flupenthixol Fluphenazine Haloperidol Loxapine Perphenazine Pimozide Thiopropazate Thioproperazine Thiothixene Trifluoperazine
First-generation antipsychotics	D2R antagonism (low potency)	Chlorpromazine Chlorprothixene Levomepromazine Mepazine Mesoridazine Methoxypromazine Pericyazine Pimozide Promazine Thioridazine
Second-generation antipsychotics	D2R antagonism	Asenapine Clozapine* Iloperidone Lurasidone Olanzapine Paliperidone Quetiapine* Risperidone Sulpiride/L-sulpiride Ziprasidone
Second-generation antipsychotics	Partial D2R agonism	Aripiprazole Brexpiprazole
Antiemetic/promotility agents	D2R antagonism	Clebopride Metoclopramide Prochlorperazine Promethazine*
Calcium channel blockers	D2R antagonism	Cinnarizine Flunarizine
Dopamine-depleting agents	Presynaptic dopamine depletion (no DR activity)	Deutetrabenazine Reserpine Tetrabenazine Valbenazine

D2R: dopamine D2 receptor; DR: dopamine receptor.
* Weak antidopaminergic properties.

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