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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Five phases of heparin-induced thrombocytopenia (HIT)

Five phases of heparin-induced thrombocytopenia (HIT)
Suspected HIT
  • Platelet count – Low
  • Heparin-PF4 assays – Not yet available
Acute HIT (confirmed diagnosis)
  • Platelet count – Low
  • Heparin-PF4 assays – Positive (functional assays and/or immunoassays)
Subacute HIT A (platelet count recovered but persistent HIT antibodies)
  • Platelet count – Recovered to normal or patient's baseline
  • Heparin-PF4 assays – Positive (functional assays and immunoassays)
Subacute HIT B (persistent HIT antibodies but functional assay no longer positive)
  • Platelet count – Recovered to normal or patient's baseline
  • Heparin-PF4 assays – Functional assay has become negative (after previously being positive); immunoassay remains positive
Remote HIT (HIT resolved, but patient remains at risk for developing acute HIT)
  • Platelet count – Normal or patient's baseline
  • Heparin-PF4 assays – Negative (after previously being positive)
Heparin-PF4 assays include functional and immunoassays; refer to UpToDate for the use of this testing and interpretation of the results. Refer to UpToDate and the source articles for guideline recommendations that relate to these phases of HIT.
HIT: heparin-induced thrombocytopenia; PF4: platelet factor 4.
Adapted from:
  1. Cuker A. Management of the multiple phases of heparin-induced thrombocytopenia. Thromb Haemost 2016; 116:835.
  2. Cuker A, Arepally GM, Chong BH, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: Heparin-induced thrombocytopenia. Blood Adv 2018; 2:3360.
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