B cell receptor and B cell coreceptor intracellular signaling events

AKT: protein kinase B; BCL6: B cell chronic lymphocytic leukemia (CLL)/lymphoma 6; BCR: B cell receptor; BLNK: B cell-linker protein; Btk: Bruton's tyrosine kinase; Ca²⁺: calcium ions; CD: cluster of differentiation; DAG: diacylglycerol; ER: endoplasmic reticulum; ERK: extracellular signal-regulated kinase; Ig: immunoglobulin; IKB: inhibitor of nuclear factor kappa-B kinase subunit beta; IKK: IKB kinase; IP₃: inositol triphosphate; IP₃R: inositol triphosphate receptor; ITAM: immunoreceptor tyrosine-based activation motif; ITIM: immunoreceptor tyrosine-based inhibition motif; MEK: mitogen-activated protein/extracellular signal-regulated kinase; mTOR: mechanistic target of rapamycin; NFAT: nuclear factor of activated T cells; NFkB: nuclear factor-kappa-B; ORAI1: calcium release-activated calcium channel protein 1; P: phosphorylation site; PI3K: phosphoinositide 3-kinase; PIP₂: phospholipid phosphatidylinositol 4,5-bisphosphate; PIP₃: phosphatidylinositol (3,4,5)-trisphosphate; PKC: protein kinase C; PLC-gamma-2: phospholipase C-gamma-2; SHIP: SH2-containing inositol phosphatase.