Impact of central sensitization

Condition	Observed impact of central sensitization
Osteoarthritis	QST and neuroimaging abnormalities improved after joint replacement Correlated with pain severity, poor outcome Correlated with opioid use
RA	Higher pain and disease activity scores but no correlation with inflammation/damage Correlated with neuropathic symptoms, QST ratings Correlated with adverse outcome, lack of remission, inappropriate therapy
Spondyloarthritis	Worse disease activity scores and outcomes Poorer response/inappropriate use of biologics
SLE	Greater mood and sleep disturbances Poorer outcome
Chronic LBP	Greater pain, mood disturbances, adverse outcome
Joint hypermobility syndrome	Correlated with pain severity, poor outcome
Chronic whiplash	Correlated with pain severity, poor outcome, cognitive disturbances
Carpal tunnel syndrome	Correlated with poor surgical outcome
Lateral epicondylitis	Correlated with pain severity, duration, poor response to treatment

QST: quantitative sensory testing; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; LBP: low back pain.

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