Fc receptors

Receptor	Cellular distribution	Principal ligand	Effects of ligation
Fc-gamma-RI (CD64)	Neutrophils Macrophages Eosinophils	High affinity for IgG1 and IgG3	Promotes phagocytosis of targets opsonized with IgG Activates respiratory burst
Fc-gamma-RIIa (CD32a)	Neutrophils Macrophages Eosinophils Platelets Langerhans cells	High affinity for IgG1 and IgG3	Promotes phagocytosis Promotes granule release from eosinophils
Fc-gamma-RIIb (CD32b)	B cells Neutrophils Macrophages Eosinophils	IgG	Inhibits BCR Inhibits phagocytosis
Fc-gamma-RIIIa (CD16a)	NK cells Macrophages Neutrophils	IgG	Activates ADCC in NK cells Promotes activation
Fc-gamma-RIIIb (CD16b)	Neutrophils Eosinophils Macrophages Mast cells Follicular dendritic cells	IgG	Removes circulating immune complexes
Fc-alpha-RI (CD89)	Neutrophils Macrophages Eosinophils	IgA	Promotes phagocytosis
Fc-epsilon-RI	Mast cells Basophils	IgE	Degranulation
Fc-epsilon-RII (CD23)	B cells Follicular dendritic cells Eosinophils	IgE	Regulates IgE and IgG production
FcRn	Monocytes Macrophages Dendritic cells Epithelial cells Endothelial cells Hepatocytes	IgG	Transplacental transfer Transfer across intestinal epithelium IgG recycling

Ig: immunoglobulin; BCR: B cell receptor; NK: natural killer; ADCC: antibody-dependent, cell-mediated cytotoxicity; FcRn: neonatal Fc receptor.

Graphic 119723 Version 1.0