Version June 2024
| Relative contraindications to pancreas-kidney transplantation |
| Age <18 or >60 years |
| BMI >30 to 35 kg/m2 |
| Daily insulin requirement >1 unit/kg |
| Insulin requiring for <3 years |
| Left ventricular ejection fraction <40% |
| Recent myocardial infarction or stroke |
| Pulmonary artery systolic pressure >50 mmHg (confirmed by right heart catheterization) |
| Active tobacco smoking (up to 1 pack/day or patient has mild smoking-related morbidities) |
| History of major unilateral or bilateral extremity amputations |
| Presence of aorto-iliac or aorto-bifemoral bypass graft |
| Symptomatic cerebrovascular or peripheral vascular disease |
| Positive thrombophilia screen or history of hypercoagulability |
| Peritoneal dialysis with history of multiple prior episodes of peritonitis |
| History of multiple previous laparotomies |
| History of previous intra-abdominal/pelvic irradiation or multiple surgical procedures |
| Severe or uncontrolled orthostasis or hypotension |
| Severe or uncontrolled gastroparesis |
| Presence of an ostomy, feeding tube, or chronic bladder drainage catheter |
| History of previous substance abuse, psychiatric illness, or noncompliance/nonadherence |
| Limited psychosocial support and resources (lives alone, relies on public transportation) |
| Jehovah's Witness who refuses blood products |
| Incurable chronic, active, or unresolved infection, including chronic active viral hepatitis B, uncontrolled hepatitis C, or uncontrolled HIV |
| Substance use disorder (eg, alcohol, tobacco, narcotics) that is either active or within the last 6 months and has not been evaluated for or entered into a structured rehabilitation or cessation program |
| Moderate to advanced cirrhosis |
| Life expectancy less than 2 years because of other irreversible systemic illness or multiple comorbidities |
| Not up to date with center-specific vaccination requirements |
| Malignancy in the last 2 years, with the exception of cutaneous squamous and basal cell tumors, that is not in complete remission or believed to be cured |
| Severe frailty, sarcopenia, deconditioning, or malnutrition |
| Limited health literacy |
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
