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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Indications for irradiated red blood cells (RBCs) and platelets

Indications for irradiated red blood cells (RBCs) and platelets
Intrauterine transfusion
Neonatal exchange transfusion*
Congenital cell-mediated immunodeficiencies*
Hodgkin lymphoma (not time-limited; applies to all transfusions during the patient's lifetime)
Hematopoietic stem cell transplant recipients (autologous or allogeneic)
Donors of allogeneic hematopoietic stem cells (only applies to the week prior to and during stem cell harvest)
CAR-T therapy recipients (applies 7 days prior to collection and 3 months post-infusion)
Purine analog therapy for any diagnosis (eg, fludarabine, cladribine, deoxycoformycin, bendamustine, clofarabine)
ATG or alemtuzumab therapy for hematologic disease (but not for other diagnoses)
Recipients of donations from biologic relatives
Recipients of donations selected on the basis of HLA matching
Irradiation is used to prevent transfusion-associated graft-versus-host-disease (ta-GVHD) in susceptible individuals. Refer to UpToDate for information about risk factors and mechanisms of ta-GVHD.
CAR-T: chimeric antigen receptor T cells; ATG: anti-thymocyte globulin; HLA: human leukocyte antigen.
* In practice, many hospitals simply provide irradiated blood to all neonates rather than risking the chance that nonirradiated blood may be given to a neonate with immunodeficiency that has not fully manifested.
Examples of congenital cell-mediated immunodeficiencies include:
  • Hemophagocytic lymphohistiocytosis
  • Thymic hypoplasia (DiGeorge syndrome)
  • Wiskott-Aldrich syndrome
  • Leiner disease
  • 5' nucleotidase deficiency
¶ Duration:
  • Autologous transplant – Irradiation should be continued for 3 months after conditioning was administered (for 6 months if total body irradiation was used).
  • Allogeneic transplant – Irradiation should be continued for at least 6 months post-transplant and until the individual is free of active chronic GVHD, is off of immunosuppression, and has a lymphocyte count >1000/microL.
Reference: Foukaneli T, Kerr P, Bolton-Maggs PHB, et al. Guidelines on the use of irradiated blood components. Br J Haematol 2020; 191:704.
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