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Community-acquired pneumonia: Risk factors for MRSA and Pseudomonas in adults

Community-acquired pneumonia: Risk factors for MRSA and Pseudomonas in adults
  MRSA Pseudomonas
Strong risk factors* Known MRSA colonization Known Pseudomonas colonization
Prior MRSA infection Prior Pseudomonas infection
Detection of gram-positive cocci in clusters on a good-quality sputum Gram stain Detection of gram-negative rods on a good-quality sputum Gram stain
Hospitalization with receipt of IV antibiotics in the prior 3 months
Other factors that should raise suspicion for infection Recent hospitalization or antibiotic use, particularly hospitalization with receipt of IV antibiotics in the prior 3 months Recent hospitalization or stay in a long-term care facility
Recent influenza-like illness Recent antibiotic use of any kind
Necrotizing or cavitary pneumonia Frequent COPD exacerbations requiring glucocorticoid and/or antibiotic use
EmpyemaΔ Other structural lung diseases (eg, bronchiectasis, cystic fibrosis)
Immunosuppression Immunosuppression
Risk factors for MRSA colonization, including:
  • End-stage kidney disease
  • Crowded living conditions (eg, incarceration)Δ
  • Injection drug useΔ
  • Contact sports participationΔ
  • Men who have sex with menΔ
 

CAP: community-acquired pneumonia; MRSA: methicillin-resistant Staphylococcus aureus; IV: intravenous; COPD: chronic obstructive pulmonary disease.

* The presence of these risk factors generally warrant empiric treatment in patients with CAP of any severity.

¶ The presence of these factors should raise suspicion for MRSA or Pseudomonas infection and generally warrants treatment in those who are severely ill; in others, the need for empiric treatment should take into account local prevalence, severity of illness, and overall clinical assessment.

Δ This factor is associated with community-acquired MRSA infection, which can cause severe toxin-mediated infection. Refer to the UpToDate topic on MRSA infections and treatment of CAP in patients with risk factors for MRSA infection for further detail.
Graphic 118967 Version 4.0

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