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Summary of sensitivity and specificity in meta-analyses evaluating PET/CT using the prostate cancer-specific tracers PSMA, choline, and fluciclovine

Summary of sensitivity and specificity in meta-analyses evaluating PET/CT using the prostate cancer-specific tracers PSMA, choline, and fluciclovine
Systematic review
and meta-analysis		 Number of studies Number of patients Sensitivity
(per lesion)
(95% CI)		 Specificity
(per lesion)
(95% CI)		 Sensitivity
(per patient)
(95% CI)		 Specificity
(per patient)
(95% CI)
PSMA
Perera[1] N = 16 N = 1309 80% (66-89) 97% (92-99) 86% (37-98) 86% (3-100)
Choline
Fanti[2] N = 12 N = 1270     89% (83-93) 89% (73-96)
Evangelista[3] N = 19 N = 1555 86% (83-88) 93% (90-95)    
Umbehr[4] N = 12 N = 1055 90% (74-97) 95% (92-97) 85% (79-89) 88% (73-95)
Shen[5] (bone metastases) N = 9 N = 423 83% (81-85) 95% (94-97) 87% (79-93) 97% (93-99)
Fluciclovine
Ren[6] N = 6 N = 251     87% (80-92) 66% (56-75)*
PET: positron emission tomography; CT: computed tomography; PSMA: prostate-specific membrane antigen.
* Meta-analysis did not include 2 recent studies evaluating operational characteristics for F-18 fluciclovine specificity. Specificity may be higher than reported.
References:
  1. Perera M, Papa N, Christidis D, et al. Sensitivity, specificity, and predictors of positive 68Ga-prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: A systematic review and meta-analysis. Eur Urol 2016; 70:926.
  2. Fanti S, Minozzi S, Castellucci P, et al. PET/CT with (11)C-choline for evaluation of prostate cancer patients with biochemical recurrence: Meta-analysis and critical review of available data. Eur J Nucl Med Mol Imaging 2016; 43:55.
  3. Evangelista L, Zattoni F, Guttila A, et al. Choline PET or PET/CT and biochemical relapse of prostate cancer: A systematic review and meta-analysis. Clin Nucl Med 2013; 38:305.
  4. Umbehr MH, Müntener M, Hany T, et al. The role of 11C-choline and 18F-fluorocholine positron emission tomography (PET) and PET/CT in prostate cancer: A systematic review and meta-analysis. Eur Urol 2013; 64:106.
  5. Shen G, Deng H, Hus S, Jia Z. Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: A meta-analysis. Skelet Radiol 2014; 43:1503.
  6. Ren J, Yuan L, Wen G, Yang J. The value of anti-1-amino-3- 18F-fluorocyclobutane-1-carboxylic acid PET/CT in the diagnosis of recurrent prostate carcinoma: A meta-analysis. Acta Radiol 2016; 57:487.
Reproduced from: Evans JD, Jethwa KR, Ost P, et al. Prostate cancer-specific PET radiotracers: A review on the clinical utility in recurrent disease. Pract Radiat Oncol 2018; 8:28. Table used with the permission of Elsevier Inc. All rights reserved.
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