NCI CTCAE v5.0 superior vena cava (SVC) syndrome

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
SVC syndrome	Asymptomatic; incidental finding of SVC thrombosis	Symptomatic, medical intervention indicated (eg, anticoagulation, radiation, or chemotherapy)	Severe symptoms; multimodality intervention indicated (eg, anticoagulation, chemotherapy, radiation, stenting)	Life-threatening consequences; urgent multimodality intervention indicated (eg, lysis, thrombectomy, surgery)	Death

SVC syndrome is characterized by obstruction of the blood flow in the SVC. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea, and headache.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; SVC: superior vena cava.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

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NCI CTCAE v5.0 superior vena cava (SVC) syndrome