The figure briefly summarizes aneurysmogenesis in the infrarenal aorta, which is susceptible to aneurysm development due to its embryology, histology, and unique hemodynamic forces. Inflammation, especially via inhibition of IFN-gamma, further degrades the strength elements of the aorta (ie, collagen, elastin, extracellular matrix proteins). Eventually, the infrarenal aorta weakens and enlarges, resulting in aneurysm.
TH2: T-helper cell type 2; IFN: interferon.
Graphic 117142 Version 1.0
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