Differential diagnosis in a child with suspected metabolic dysfunction-associated steatotic liver disease^[1]

Genetic/metabolic

Lysosomal acid lipase deficiency

Wilson disease

Fatty acid oxidation defects and other mitochondrial disorders

Partial/total lipodystrophy

Abetalipoproteinemia or hypobetalipoproteinemia

Immune-mediated

Celiac disease

Autoimmune hepatitis

Endocrine

Panhypopituitarism

Hypothyroidism

Uncontrolled diabetes

Infectious

Hepatitis C (genotype 3)

HIV-related lipodystrophy

Iatrogenic

Certain psychotropic medications

Corticosteroids

Other medications – Methotrexate, amiodarone

Rapid surgical weight loss

Parenteral nutrition

HIV: human immunodeficiency virus; MASLD: metabolic dysfunction-associated steatotic liver disease (formerly known as nonalcoholic fatty liver disease [NAFLD]).

Reference:

Vos MB, Abrams SH, Barlow SE, et al. NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). J Pediatr Gastroenterol Nutr 2017; 64:319.

Graphic 116582 Version 3.0

خرید پکیج

Differential diagnosis in a child with suspected metabolic dysfunction-associated steatotic liver disease[1]

Differential diagnosis in a child with suspected metabolic dysfunction-associated steatotic liver disease^[1]