International Myeloma Working Group diagnostic criteria for systemic AL amyloidosis

Diagnosis of systemic AL amyloidosis requires all of the following:

Presence of an amyloid-related systemic syndrome (eg, renal, liver, heart, gastrointestinal tract, or peripheral nerve involvement)

Positive amyloid staining by Congo red in any tissue (eg, fat aspirate, bone marrow, or organ biopsy)

Evidence that amyloid is light-chain-related established by direct examination of the amyloid using mass spectrometry-based proteomic analysis, or immunoelectronmicroscopy, and

Evidence of a monoclonal plasma cell proliferative disorder (serum or urine monoclonal protein, abnormal free light-chain ratio, or clonal plasma cells in the bone marrow)

AL: amyloid light chain.

Adapted from: Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 2014; 15:e538.

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International Myeloma Working Group diagnostic criteria for systemic AL amyloidosis