Relationship between undissociated uric acid, total uric acid, and urinary pH
Relationship between undissociated uric acid, total uric acid, and urinary pH
The limit of solubility of undissociated uric acid is depicted by the dotted line (approximately 100 mg/L). Two hypothetical urine pHs are considered (two arrows). At low urinary pH (eg, 5.0), even a modest amount of total urinary uric acid will exceed its solubility. At high urine pH (eg, 6.5), even massive hyperuricosuria is well tolerated.