AL amyloidosis: Hematologic response and progression criteria

Response category	Criteria
Complete	Normalization of the free light chain levels and ratio, negative serum and urine immunofixation
Very good partial	Reduction in the dFLC to <40 mg/L
Partial	A greater than 50% reduction in the dFLC
No response	Less than a PR
Progression	From CR, any detectable monoclonal protein or abnormal free light chain ratio (light chain must double) From PR, 50% increase in serum M protein to >0.5 g/dL or 50% increase in urine M protein to >200 mg/day (a visible peak must be present) Free light chain increase of 50% to >100 mg/L

FLC: free light chain; dFLC: difference between involved FLC and uninvolved FLC; PR: partial response; CR: complete response.

Reprinted by permission from: Macmillan Publishers Ltd: Leukemia. Comenzo RL, Reece D, Palladini G, et al. Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis. Leukemia 2012; 26:2317. Copyright © 2012. https://www.nature.com/leu/.

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AL amyloidosis: Hematologic response and progression criteria