Vaginal progesterone desensitization

Protocol step	Vaginal suppositories dose (mg)	Number of suppositories	Total dose	Time interval (minutes)
1	0.05	1	0.05	20
2	0.05	2	0.1	20
3	0.5	1	0.5	20
4	0.5	2	1	20
5	5	1	5	20
6	5	2	10	20
7	50	1	50	20
8	50	2	100	20

Note that this protocol has been performed in a very small number of patients by experienced allergy specialists. The efficacy in larger numbers of patients awaits further study. UpToDate suggests that allergy specialists supervise such protocols whenever possible.

Original figure modified for this publication. Reproduced from: Prieto-Garcia A, Sloane DE, Gargiulo AR, et al. Autoimmune progesterone dermatitis: Clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil Steril 2011; 95:1121.e9. Table used with the permission of Elsevier Inc. All rights reserved.

Graphic 116118 Version 2.0

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Vaginal progesterone desensitization