Skin cleanser, procedural (eg, phleobotomy, central line placement [PICC, UAC], line maintenance care): Note: Guidelines for pediatric patients and adults recommend using a >0.5% chlorhexidine preparation in alcohol; however, no recommendations are provided for neonates and infants <2 months (IDSA [O’Grady 2011]). NICU specific recommendations suggest no preferred agent, but advise against using tincture of iodine (AAP [Polin 2012]); most neonatal studies have used a 2% chlorhexidine and alcohol preparation (Chapman 2013; Garland 2009; O’Connor 2016); a few studies have used a 0.5% chlorhexidine concentration (Garland 1995; Garland 1996). It is recommended to use chlorhexidine-containing products with care in this population due to potential risk of dermal irritation or chemical burns.
Premature or term neonates with body weight >1.5 kg and PNA >7 days: Limited data available: Topical: Cleanse site with chlorhexidine product for ~30 seconds, allow to dry (~30 to 60 seconds) prior to line insertion, dressing application or lab draw (Chapman 2013; Garland 1995; Garland 2009; O’Connor 2016). Note: Minimal age and weight variable; use has been evaluated in ELBW neonates with GA as young as 24 weeks and birth weight as low as 630 g (Chapman 2013); some studies suggest, however, an increased risk of skin irritation and burns with decreased maturity and bodyweight (AAP [Polin 2010]; Garland 1996; Garland 2009; Tamma 2010); risk versus benefit must be weighed prior to use in neonates.
Skin cleanser for preoperative skin preparation, skin wound and general skin cleanser for patients: Topical:
Infants <2 months: Note: It is recommended to use with care in this population due to potential risk of dermal irritation or chemical burns. Expert suggestions are variable depending upon site and clinical scenario. Not all products may be appropriate for use in this population; refer to product specific labeling. Some experience in neonatal patients applicable to this patient population (Garland 2009; Tamma 2010).
Preoperative skin preparation: Solution: Apply liberally to surgical site and swab for at least 2 minutes. Dry with sterile towel. Repeat procedure (swab for additional 2 minutes and dry with sterile towel).
Wound care and general skin cleansing: Rinse area with water, then apply the minimum amount of chlorhexidine necessary to cover skin or wound area and wash gently. Rinse again thoroughly.
Infants ≥2 months, Children, and Adolescents: Topical solution:
Preoperative skin preparation: Solution: Apply liberally to surgical site and swab for at least 2 minutes. Dry with sterile towel. Repeat procedure (swab for additional 2 minutes and dry with sterile towel).
Wound care and general skin cleansing: Rinse area with water, then apply the minimum amount of chlorhexidine necessary to cover skin or wound area and wash gently. Rinse again thoroughly.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
(For additional information see "Chlorhexidine gluconate (topical): Drug information")
Note: General dosing guidelines provided; refer to specific product labeling for dosing instructions.
Antiseptic:
Health care personnel hand antiseptic: Liquid or solution: Topical: Wash with ~5 mL for 15 seconds; rinse thoroughly with water and dry
Preoperative skin preparation:
Solution: Topical: Apply liberally to surgical site and swab for at least 2 minutes. Dry with sterile towel. Repeat procedure (swab for additional 2 minutes and dry with sterile towel).
Applicator (ChloraPrep One-Step):
Dry surgical sites (eg, abdomen, arm): Topical: Completely wet treatment area; use gentle back and forth strokes for ~30 seconds. Allow solution to air dry for ~30 seconds. If using an ignition source (eg, electrocautery), allow solution to completely dry for a minimum of 3 minutes for hairless skin and up to 1 hour in hair; do not blot or wipe away. Note: Prior to use with electrocautery procedures, consult specific product labeling to determine if the ChloraPrep product may be used near an ignition source.
Moist surgical sites (eg, inguinal area): Topical: Completely wet treatment area; use gentle back and forth strokes for ~2 minutes. Allow solution to air dry for ~ 1 minute. If using an ignition source (eg, electrocautery), allow solution to completely dry for a minimum of 3 minutes for hairless skin and up to 1 hour in hair; do not blot or wipe away. Note: Prior to use with electrocautery procedures, consult specific product labeling to determine if the ChloraPrep product may be used near an ignition source.
Staphylococcus aureus (including methicillin-resistant) decolonization:
Note: For select patients who have recurrent S. aureus infection or warrant decolonization (eg, preoperative decolonization, patients in the ICU, patients hospitalized with central venous or midline catheters, patients colonized with methicillin-resistant S. aureus at hospital discharge) (CDC 2024; Huang 2019; IDSA [Liu 2011]).
Liquid or Solution: Topical: Rinse entire body with water, then wash with minimum amount necessary to cover entire body daily; use in combination with nasal mupirocin. Duration of chlorhexidine is typically 5 to 14 days but may be extended in patients in the ICU and/or in patients with central venous or midline catheters (Bode 2010; CDC 2024; IDSA [Liu 2011]; Lee 2013). For decolonization at hospital discharge, some experts suggest a 5-day course in combination with nasal mupirocin and chlorhexidine mouthwash repeated twice monthly for 6 months (Huang 2019).
Surgical scrub: Topical: Scrub hands and forearms with ~5 mL for 3 minutes paying close attention to nails, cuticles, and interdigital spaces, and rinse thoroughly; wash for an additional 3 minutes with 5 mL, rinse, and dry thoroughly.
Wound care and general skin cleansing: Topical: Rinse area with water, then apply minimum amount necessary to cover skin or wound area and wash gently. Rinse again thoroughly.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Dermatologic: Allergic sensitization, erythema, hypersensitivity reaction, rough skin, xeroderma
<1%, postmarketing, and/or case reports: Anaphylaxis (Health Canada May 2016), dyspnea, facial edema, nasal congestion
OTC labeling: When used for self-medication, do not use in patients hypersensitive to chlorhexidine or any component of the formulation; in contact with meninges; in genital area; electrocautery procedures (ChloraPrep); open skin wounds or as general skin cleanser (ChloraPrep).
Concerns related to adverse effects:
• Hypersensitivity reactions: Serious allergic reactions, including anaphylaxis, have been reported.
Dosage form specific issues:
• Topical: For topical use only. Keep out of eyes, ears, and the mouth; if contact occurs, rinse with cold water immediately; permanent eye injury may result if agent enters and remains in the eye. Deafness has been reported following instillation in the middle ear through perforated ear drums. Avoid applying to wounds that involve more than the superficial skin layers. Avoid repeated use as general skin cleansing of large surfaces (unless necessary for condition). Not for preoperative preparation of face or head; do not use on lumbar puncture sites. Solutions may be flammable (products may contain alcohol); avoid exposure to open flame and/or ignition source (eg, electrocautery) until completely dry; avoid application to hairy areas which may significantly delay drying time. Use with caution in children <2 months of age due to potential for increased absorption, and risk of irritation or chemical burns. May cause staining of fabrics (brown stain) due to a chemical reaction between chlorhexidine gluconate bound to fabric and chlorine (if sufficient chlorine is present from certain laundry detergents used during laundering process).
Other warnings/precautions:
• Appropriate use: Topical: When used as a topical antiseptic, improper use may lead to product contamination. Although infrequent, product contamination has been associated with reports of localized and systemic infections. To reduce the risk of infection, ensure antiseptic products are used according to the labeled instructions; avoid diluting products after opening; and apply single-use containers only one time to one patient and discard any unused solution (FDA Drug Safety Communication 2013).
Although topical chlorhexidine is widely used in many NICUs as a skin cleanser prior to procedures (eg, central venous line placement/care) (Tamma 2010), data is lacking to support use in premature infants. Manufacturer's labeling recommends using with caution in premature neonates and infants <2 months of age as chlorhexidine-containing products may cause irritation or chemical burns. A survey of US NICU chlorhexidine use reports dermal burns occurring more frequently in neonates with birth weight <1,500 g (Tamma 2010). If used for neonatal dermal site cleansing, some suggest using sterile water or normal saline to remove excess disinfectant after procedures may help avoid chemical burns (Eichenwald 2017; Nuntnarumit 2013). Several studies have noted detectable serum concentrations in neonates after chlorhexidine exposure; no correlation between serum concentration and GA, birth weight, or PNA was identified; the clinical significance is undetermined (Chapman 2013; Garland 2009).
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Liquid, External:
Betasept Surgical Scrub: 4% (118 mL, 237 mL, 473 mL, 946 mL)
Hibiclens: 4% (15 mL, 118 mL, 236 mL, 473 mL, 946 mL, 3790 mL) [contains fd&c red #40 (allura red ac dye), isopropyl alcohol]
Generic: 2% (118 mL [DSC]); 4% (118 mL [DSC], 237 mL [DSC], 473 mL [DSC], 946 mL [DSC], 3800 mL [DSC])
Miscellaneous, External:
Biopatch Protective Disk/CHG: (Dressing) (10 ea)
Tegaderm CHG Dressing: (Dressing) (1 ea [DSC])
Pad, External:
Generic: 2% (2 ea, 6 ea)
Solution, External:
Chlorhexidine Gluconate: 2% (118 mL) [latex free; contains isopropyl alcohol]
Dyna-Hex 2: 2% (473 mL) [contains isopropyl alcohol]
Dyna-Hex 4: 4% (118 mL, 473 mL) [contains isopropyl alcohol]
FT Antiseptic Skin Cleanser: 4% (237 mL) [dye free; contains isopropyl alcohol]
Generic: 4% (118 mL, 236 mL, 473 mL)
May be product dependent
Liquid (Betasept Surgical Scrub External)
4% (per mL): $0.04
Liquid (Hibiclens External)
4% (per mL): $0.03
Misc (Biopatch Protective Disk/CHG External)
(Dressing) (per each): $8.83
Solution (Chlorhexidine Gluconate External)
4% (per mL): $0.04
Solution (Dyna-Hex 2 External)
2% (per mL): $0.01
Solution (Dyna-Hex 4 External)
4% (per mL): $0.04
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: Keep out of eyes, ears, and mouth. Do not routinely apply to wounds which involve more than superficial layers of skin. Avoid contact with meninges (ie, do not use on lumbar puncture sites). Solutions may be flammable (may contain alcohol); consult specific product labeling to determine if product may be used with electrocautery procedures; if product can be used near an ignition source (eg, cautery, laser), avoid exposure to open flame and/or ignition source until completely dry; avoid application to hairy areas which may significantly delay drying time. When using the ChloraPrep applicator, do not touch sponge. Hold applicator sponge down and pinch wings of applicator once to activate ampul and release antiseptic.
Topical: Keep out of eyes, ears, and mouth. Do not routinely apply to wounds which involve more than superficial layers of skin. Avoid contact with meninges (ie, do not use on lumbar puncture sites). Solutions may be flammable (may contain alcohol); consult specific product labeling to determine if product may be used with electrocautery procedures; if product can be used near an ignition source (eg, cautery, laser), avoid exposure to open flame and/or ignition source until completely dry; avoid application to hairy areas which may significantly delay drying time. When using the ChloraPrep applicator, do not touch sponge. Hold applicator sponge down and pinch wings of applicator once to activate ampul and release antiseptic.
Store at room temperature. Alcohol-containing topical products are flammable; keep away from flames or fire.
Topical: Skin cleanser for preoperative skin preparation, prior to injection; skin wound and general skin cleanser for patients (FDA approved in pediatric patients [age not specified] and adults); surgical scrub and antiseptic hand rinse for health care personnel (FDA approved in adults). Note: Indications vary by product; refer to specific product labeling for details.
KIDs List: Chlorhexidine, when used in very low birthweight neonates, is identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be used with caution due to risk of chemical burns (strong recommendation; low quality of evidence) (PPA [Meyers 2020]).
None known.
There are no known significant interactions.
No reports of adverse effects in newborns have been reported, even though chlorhexidine is commonly used during labor and in the neonate. Moreover, only very small amounts of disinfectant reach the maternal circulation and the fetus.
Topical: Monitor for redness/skin irritation especially in infants <2 months
Chlorhexidine has activity against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast; it is both bacteriostatic and bactericidal, depending on its concentration. The bactericidal effect of chlorhexidine is a result of the binding of this cationic molecule to negatively charged bacterial cell walls and extramicrobial complexes. At low concentrations, this causes an alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorous resulting in a bacteriostatic effect. At high concentrations of chlorhexidine, the cytoplasmic contents of the bacterial cell precipitate and result in cell death.
Absorption: Topical: Neonates: Detectable serum concentrations have been noted following topical chlorhexidine administration (Chapman 2013; Cowen 1979; Garland 2009)
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟