Point-of-care diagnostic tests for sickle cell disease

Test name	Method/ platform	Able to distinguish between the listed genotypes				Able to detect SCD in newborns?
Test name	Method/ platform	SS versus AA	SS versus AS	AS versus AA	SC versus non-SC	Able to detect SCD in newborns?
Gazelle Hb Variant*	Microchip electrophoresis	Yes	Yes	Yes	Yes	Yes
HemoTypeSC	Competitive lateral flow immunoassay	Yes	Yes	Yes	Yes	Yes
Sickle SCAN	Lateral flow immunoassay	Yes	Yes	Yes	Yes	Yes

These point-of-care (POC) tests can be performed at or near the patient without the need for transport to a laboratory or use of laboratory equipment. Some POC tests are no longer under development, such as the Sickle Dx (paper-based diffusion) and the aqueous multiphase system (AMPS). Refer to UpToDate for additional information about diagnostic testing for sickle cell disease.

POC: point-of-care; SCD: sickle cell disease; Hb: hemoglobin.

* Previously "HemeChip".

Original table modified for this publication. From: McGann PT, Hoppe C. The pressing need for point-of-care diagnostics for sickle cell disease: A review of current and future technologies. Blood Cells Mol Dis 2017; 67:104. Table used with the permission of Elsevier Inc. All rights reserved.

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Point-of-care diagnostic tests for sickle cell disease