IM progesterone desensitization protocol for IVF

Time	Dose (IM progesterone 50 mg/mL)
0 minutes	1 mg
30 minutes	2 mg
60 minutes	4 mg
90 minutes	8 mg
120 minutes	16 mg
150 minutes	18.5 mg
Total dose	50 mg
Target daily dose	Intravaginal progesterone 90 to 180 mg (ie, 8% gel once or twice daily) or IM progesterone 50 to 75 mg daily, depending on IVF protocol

Patients were premedicated with H1 and H2 blockers completed in an outpatient infusion center with a registered nurse trained in desensitization.
Note that this protocol has been performed in a very small number of patients by experienced allergy specialists. The efficacy in larger numbers of patients awaits further study. UpToDate suggests that allergy specialists supervise such protocols whenever possible.

IM: intramuscular; IVF: in vitro fertilization.

Reproduced from: Foer D, Buchheit JM, Gargiulo AR, et al. Progesterone hypersensitivity in 24 cases: Diagnosis, management, and proposed renaming and classification. J Allergy Clin Immunol Pract 2016; 4:723. Table used with the permission of Elsevier Inc. All rights reserved.

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IM progesterone desensitization protocol for IVF