Version May 2024
| Necrotizing fasciitis | Pyoderma gangrenosum |
| No association with inflammatory bowel disease | Strong link with inflammatory bowel disease |
| Rapid progression | Slower progression within days |
| Can resemble cellulitis in early stage | Does not resemble cellulitis |
| Violaceous ulcer edge not a typical feature | Violaceous ulcer edge is typical |
| Septic picture can develop | Unlikely to develop sepsis |
| Likely to require intensive care | Unlikely to require intensive care |
| Responds to surgery | Worsens with surgery |
| Lack of resistance to blunt dissection of fascial planes | Fascial planes have normal resistance to dissection |
| Worsens with immunosuppressive therapy | Responds to immunosuppressive therapy |
| Should respond to antibiotics and surgery | No response to antibiotics and worsens with surgery |
| Usually positive blood and tissue cultures | Usually negative blood and tissue cultures |
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