| | Bleeding complications | Thromboembolic complications | Complications of pregnancy | Other findings (rare) |
| Afibrinogenemia | - Common
- Can be severe
- Can occur during neonatal period (eg, umbilical cord bleeding)
- Sites may include gastrointestinal, urinary, central nervous system, spleen (with splenic rupture)
| - Possible
- May be venous or arterial
| - Spontaneous abortion, early fetal loss, and/or placental abruption may occur
- Can have bleeding antepartum or postpartum
| - Bone cysts
- Abnormal wound healing
|
| Hypofibrinogenemia | - Variable frequency
- Variable severity
| - Rare but possible
- May be venous or arterial
| - Spontaneous abortion may occur; the likelihood of successful pregnancy appears to correlate with the fibrinogen level
- Can have bleeding antepartum or postpartum
| |
| Dysfibrinogenemia and hypodysfibrinogenemia | - Variable frequency; affects less than half of individuals
- Most bleeding is mild, but severe bleeding can occur
- Common sites include menorrhagia and skin bleeding
| - More common than bleeding; may affect up to 30% of individuals
- May occur in the setting of fibrinogen replacement therapy
| - Spontaneous abortion and postpartum hemorrhage may occur
| - Renal amyloidosis secondary to mutant fibrinogen (alpha-chain)
|
