Evaluation for a suspected fibrinogen disorder

PT: prothrombin time; aPTT: activated partial thromboplastin time; TT: thrombin time; RT: reptilase time; HTC: hemophilia treatment center; DIC: disseminated intravascular coagulation.
* A fibrinogen disorder may be suspected in an individual with unexplained bleeding and/or thrombosis (typically, some of the more common causes of these findings such as anticoagulation, thrombocytopenia, or DIC have been eliminated) or in an individual with a known family history of a congenital fibrinogen disorder.
¶ Specialized testing for congenital afibrinogenemia may include genetic testing or analysis in a specialized laboratory. Additional testing for hypofibrinogenemia or dysfibrinogenemia depends on the clinical presentation and may include genetic testing or specialized laboratory testing for congenital disorders and/or testing for acquired conditions. Rarely, hypodysfibrinogenemia may be present. A coagulation specialist or HTC can assist with the evaluation, urgent management, and development of a comprehensive treatment plan.