NCI CTCAE v5.0 injection site reactions

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Injection site reaction	Tenderness with or without associated symptoms (eg, warmth, erythema, itching)	Pain; lipodystrophy; edema; phlebitis	Ulceration or necrosis; severe tissue damage; operative intervention indicated	Life-threatening consequences; urgent intervention indicated	Death

An injection site reaction is a disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

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