Category | Children | Adults |
General health | Testing prior to transfusion and possible transplant (all done once at initial evaluation):
| Testing prior to transfusion and possible transplant (all done once if not already available):
|
Assessment of iron overload:
| Assessment of iron overload:
| |
CBC, reticulocyte count, and assessment of kidney function at each visit | CBC, reticulocyte count, and assessment of kidney function at each visit | |
Chemistry panel including serum calcium every 3 months | Chemistry panel including serum calcium every 3 to 6 months | |
Urinalysis every 6 months | ||
Growth and development:
| Growth and development:
| |
Routine dental evaluation every 6 months | Routine dental evaluation every 6 months | |
Vision screening every 3 months; ophthalmology examination annually | Routine ophthalmology examination every 6 months | |
Audiology screen annually | ||
Specific organ systems | Hematology:
| Hematology:
|
Hepatology:
| Hepatology:
| |
Cardiopulmonary:
| Cardiopulmonary:
| |
Endocrinology:
| Endocrinology:
|
HLA: human leukocyte antigen; DNA: deoxyribonucleic acid; RBC: red blood cell; TIBC: total iron binding capacity; TSAT: transferrin saturation; MRI: magnetic resonance imaging; CBC: complete blood count; AST: aspartate aminotransferase; ALT: alanine aminotransferase; PCR: polymerase chain reaction; PT: prothrombin time; aPTT: activated partial thromboplastin time; TSH: thyroid-stimulating hormone; PTH: parathyroid hormone; HbA1c: glycosylated hemoglobin; IGF-1: insulin-like growth factor-1; IGFBP-3: IGF binding protein 3; LH-ICMA: luteinizing hormone-immunochemiluminometric assay; FSH: follicle-stimulating hormone.
* Chronic hemolysis and transfused RBCs both can artifactually lower the HbA1c and provide misleading information regarding glucose regulation, especially if used as a one-time isolated test. For diabetes screening, fasting blood glucose and an oral glucose tolerance test should be included in the diagnostic thinking. For individuals with steady state transfusion requirements and clinical stability, the HbA1c may be useful to follow as a means of monitoring changes from their baseline (using their prior values as a reference for detecting changes over time).آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟