Conditions associated with autoimmune hemolytic anemia (AIHA)

Warm autoimmune hemolytic anemia

Immune deficiency syndrome (eg, CVID, HIV)

Infection (viral, babesiosis)

Lymphoid malignancy (eg, CLL, NHL, MM, LGL leukemia)

Autoimmune condition (eg, SLE, ALPS)

Drug/medication*

Cold agglutinin disease

Infection (eg, atypical pneumonia [mycoplasma] or infectious mononucleosis [EBV], listeria)

Monoclonal gammopathy

Lymphoid malignancy (eg, CLL, NHL, MM)

Autoimmune hemolytic anemia may occur in an otherwise healthy individual or in the setting of a predisposing condition. Any form of hemolytic anemia can lead to an underestimation of the hemoglobin A1C (HbA1C). Refer to UpToDate for details of the evaluation and treatment.

CVID: common variable immunodeficiency; HIV: human immunodeficiency virus; CLL: chronic lymphocytic leukemia; NHL: non-Hodgkin lymphoma; MM: multiple myeloma; LGL: large granular lymphocyte; SLE: systemic lupus erythematosus; ALPS: autoimmune lymphoproliferative syndrome; EBV: Epstein-Barr virus; AIHA: autoimmune hemolytic anemia.
* Many drugs have been associated with AIHA; refer to separate table in UpToDate for an extensive list.

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Conditions associated with autoimmune hemolytic anemia (AIHA)