Factors for and against an aggressive approach for the treatment of rabies

Factors favoring initiation of an aggressive approach	Factors against initiation of an aggressive approach
Young age	Older age
Previously healthy	Medical comorbidities/immune compromise
One or more doses of rabies vaccine administered prior to the onset of clinical symptoms	No previous history of administration of rabies vaccine
Early clinical rabies (eg, local sensory symptoms)	Late clinical rabies (eg, quadriparesis or coma)
Presence of neutralizing anti-rabies virus antibodies in serum and/or cerebrospinal fluid	Absence of neutralizing anti-rabies virus antibodies in serum and/or cerebrospinal fluid
Diagnostic tests negative for rabies virus antigen and rabies virus RNA	Diagnostic tests positive for rabies virus antigen and rabies virus RNA
Access to critical care facilities	Lack of access to critical care facilities
Acceptance that the outcome could result in severe neurological deficits	Lack of acceptance that the outcome could result in severe neurological deficits

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