Algorithm for rapid oral administration of aspirin to an adult patient with a history of NSAID hypersensitivity (to target dose of 81 mg or 100 mg)^*

For important information on the safe use of these protocols (eg, appropriate settings, indications, and contraindications), refer to the UpToDate topic on introduction of aspirin to patients with aspirin hypersensitivity requiring cardiovascular interventions.

ICS/LABA: inhaled corticosteroid/long-acting beta-agonists; NSAID: nonsteroidal antiinflammatory drug.

* These are the two common low-dose tablets of aspirin available around the world.

¶ The protocol is continued, even if the patient develops symptoms. The patients who most commonly develop symptoms are those with AERD. The additional dose at the end of the procedure typically does not cause further symptoms, demonstrating that the patient is desensitized.

Adapted from: White AA, Stevenson DD, Woessner KM, Simon RA. Approach to patients with aspirin hypersensitivity and acute cardiovascular emergencies. Allergy Asthma Proc 2013; 34:138.

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Algorithm for rapid oral administration of aspirin to an adult patient with a history of NSAID hypersensitivity (to target dose of 81 mg or 100 mg)*

Algorithm for rapid oral administration of aspirin to an adult patient with a history of NSAID hypersensitivity (to target dose of 81 mg or 100 mg)^*